2021-03-08-minutes-public-works-study-session

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Specific Target Organ Systemic Toxicity (Single Exposure) Evaluation of available data suggests that this material is not an STOT-SE toxicant. Specific Target Organ Systemic Toxicity (Repeated Exposure) For the active ingredient(s): Based on available data, repeated exposures are not anticipated to cause significant adverse effects. For the major component(s): Based on available data, repeated exposures are not anticipated to cause significant adverse effects. For the minor component(s): In animals, effects have been reported on the following organs: Blood, kidney, liver, and spleen. Carcinogenicity For the active ingredient(s): Did not cause cancer in laboratory animals. For the major component(s): No relevant data found. Teratogenicity For the active ingredient(s): Did not cause birth defects or any other fetal effects in laboratory animals. For the major component(s): No relevant data found. For the minor component(s): Has caused birth defects in laboratory animals only at doses toxic to the mother. Has been toxic to the fetus in laboratory animals at doses toxic to the mother. These concentrations exceed relevant human dose levels. Reproductive toxicity For the active ingredient(s): In animal studies, did not interfere with reproduction. For the major component(s): In animal studies, did not interfere with reproduction. In animal studies, did not interfere with fertility. Mutagenicity In vitro genetic toxicity studies were negative. Animal genetic toxicity studies were negative. Aspiration Hazard Based on physical properties, not likely to be an aspiration hazard. No aspiration toxicity classification Section 12. Ecological information Ecotoxico/ogical information appears in this section when such data is available. Toxicity Acute toxicity to fish Material is practically non-toxic to fish on an acute basis (LC50 > 100 mg/L). EC50, Cyprinus carpio (Carp), static test, 96 Hour, > 120 mg/I, OECD Test Guideline 203 or Equivalent Acute toxicity to aquatic invertebrates Material is slightly toxic to aquatic invertebrates on an acute basis (LC50/EC50 between 10 and 100 mg/L). EC50, Daphnia magna (Water flea), 48 Hour, 49 mg/l, OECD Test Guideline 202 Acute toxicity to algae/aquatic plants Material is very highly toxic to some aquatic vascular plant species. ErC50, Pseudokirchneriella subcapitata (green algae), 72 Hour, > 5.4 mg/l, OECD Test Guideline 201 ErC50, Myriophyllum spicatum, 14 d, 0.000919 mg/I NOEC, Myriophyllum spicatum, 14 d, 0.0000954 mg/I Page 6 of 11